Phosphodiesterase-5 inhibitors: Emerging nephroprotective drugs

Phosphodiesterase-5 inhibitors: Emerging nephroprotective drugs

Phosphodiesterase-5 Inhibitors: Potential Nephroprotective Agents

Zaher Armaly1 and Zaid Abassi2,3* 1Departmentof Nephrology, EMMS Nazareth–The Nazareth Hospital, Nazareth and Galilee Medical School-Bar Ilan University, Safed, Israel 2Research Unit, Rambam Health Care Campus Haifa, Israel 3Department of Physiology, Rappaport Faculty of Medicine, Technion–Israel Institute of Technology, Haifa, Israel *Corresponding author: Zaid Abassi, Department of Physiology...

Emerging new uses of phosphodiesterase-5 inhibitors in cardiovascular diseases.

Phosphodiesterase type-5 (PDE-5) is an enzyme that catalyzes the hydrolytic degradation of cyclic GMP - an essential intracellular second messenger that modulates diverse biological processes in living cells. Three selective inhibitors of PDE-5 - sildenafil, vardenafil and tadalafil - have been successfully used by millions of men worldwide for the treatment of erectile dysfunction. Also, silde...

Phosphodiesterase Inhibitors as Immunomodulatory Drugs

Los niveles intracelulares de nucleótidos cíclicos (cAMP, cGMP) tienen un papel esencial en la regulación de múltiples funciones de las células inmunes. Las fosfodiesterasas (FDEs) son un grupo grande de enzimas que ejercen un papel muy importante en la regulación de los niveles intracelulares de nucleótidos cíclicos. La pentoxifilina es un inhibidor no específico de FDE que tiene diferentes ef...

Evolution of Phosphodiesterase-5 Inhibitors.

Correspondence to: Du Geon Moon Department of Urology, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea. Tel: +82-2-2626-3201, Fax: +82-2-2626-1321, E-mail: [email protected] Copyright © 2015 Korean Society for Sexual Medicine and Andrology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://c...